NRAS Mutation Is the Sole Recurrent Somatic Mutation in Large Congenital Melanocytic Nevi
نویسندگان
چکیده
منابع مشابه
Congenital Melanocytic Nevi
Figure 1. The surgical incision is marked for first-stage serial excision. DESCRIPTION A 4-year-old girl presented with congenital melanocytic nevus on the right forearm.
متن کاملCongenital giant melanocytic nevi
Nevi are common skin tumors caused by abnormal overgrowth of cells from the epidermal and dermal layers of the skin. Most nevi are benign, but some pre-cancerous nevi must be monitored or removed. The giant congenital nevus is greater than 10 cm in size, pigmented and often hairy. Between 4% and 6% of these lesions will develop into a malignant melanoma. Since approximately 50% of the melanoma ...
متن کاملIdentification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens
DLEC1 has been suggested as a tumor suppressor gene in several cancers. DLEC1 D215N somatic mutation (COSM36702) was identified in a melanoma cell line through whole genome sequencing. However, little is known about the implication and prevalence of this mutation in primary melanomas or in melanocytic nevi. The aim of this study was to genotype DLEC1 D215N mutation in melanoma tissue and melano...
متن کاملBRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi.
Purpose To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Methods Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all ...
متن کاملManagement of large congenital melanocytic nevi: art versus science.
T he management of large congenital melanocytic nevi (LCMN) has received significant attention in the medical literature during the past decade. Unfortunately, this is a topic where the ‘‘art’’ of medicine has filled the void created by the lack of ‘‘science.’’ One of the problems with collecting data regarding therapeutic options in LCMN is that the condition is rare. The ‘‘watch and wait’’ ap...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2014
ISSN: 0022-202X
DOI: 10.1038/jid.2013.429